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Koch & Reimer, 2012)

Inadequate B12 levels impair: High-Risk Groups for Vitamin B12 Deficiency Vegetarians and Vegans Plant-based diets naturally contain minimal vitamin B12, as this nutrient occurs primarily in animal products

Ischemia-induced oxidative stress and inflammation worsen epithelial damage, which leads in an increased permeability of the intestinal lining, allowing the transfer of bacteria, their products, and toxins from the gut lumen into the circulation (Liao et al., 2022)

Erythrocytes containing a small amount of reduced glutathione are relatively easily destroyed

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Pernicious anaemia is a megaloblastic anaemia, because a lack of vitamin B12 also commonly referred to as cobalamin can cause abnormality in haematopoietic cell maturation[2]